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Insulin Receptor Isoforms in Cancer
The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes. In many cancers, IR is overexpressed preferentially as IR-A isoform, deriv...
Enregistré dans:
| Publié dans: | Int J Mol Sci |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6274710/ https://ncbi.nlm.nih.gov/pubmed/30453495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19113615 |
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