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Insulin Receptor Isoforms in Cancer

The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes. In many cancers, IR is overexpressed preferentially as IR-A isoform, deriv...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Vella, Veronica, Milluzzo, Agostino, Scalisi, Nunzio Massimo, Vigneri, Paolo, Sciacca, Laura
Format: Artigo
Langue:Inglês
Publié: MDPI 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274710/
https://ncbi.nlm.nih.gov/pubmed/30453495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19113615
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