Insulin Receptor Isoforms in Cancer

The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes. In many cancers, IR is overexpressed preferentially as IR-A isoform, deriv...

Full description

Saved in:
Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Vella, Veronica, Milluzzo, Agostino, Scalisi, Nunzio Massimo, Vigneri, Paolo, Sciacca, Laura
Format: Artigo
Language:Inglês
Published: MDPI 2018
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274710/
https://ncbi.nlm.nih.gov/pubmed/30453495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19113615
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items