Interleukin-1β Promotes Gastric Atrophy Through Suppression of Sonic Hedgehog

BACKGROUND & AIMS: In both human subjects and rodent models, Helicobacter infection leads to a decrease in Shh expression in the stomach. Sonic Hedgehog (Shh) is highly expressed in the gastric corpus and its loss correlates with gastric atrophy. Therefore, we tested the hypothesis that proinfla...

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Autors principals: Waghray, Meghna, Zavros, Yana, Saqui-Salces, Milena, El-Zaatari, Mohamad, Alamelumangapuram, C. Bharath, Todisco, Andrea, Eaton, Kathryn A., Merchant, Juanita L.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895809/
https://ncbi.nlm.nih.gov/pubmed/19883649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.10.043
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