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Inhibition of Hedgehog Signaling in the Gastrointestinal Tract: Targeting the Cancer Microenvironment

This review summarizes emerging information regarding the Hedgehog (Hh) signaling pathway during neoplastic transformation in the gastrointestinal tract. Although there is a role for the well-established canonical pathway in which Hedgehog ligands interact with their receptor Patched, there is suffi...

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Detalhes bibliográficos
Main Authors: Merchant, Juanita L., Saqui-Salces, Milena
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823758/
https://ncbi.nlm.nih.gov/pubmed/24007940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ctrv.2013.08.003
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