Interleukin-1β Promotes Gastric Atrophy Through Suppression of Sonic Hedgehog

BACKGROUND & AIMS: In both human subjects and rodent models, Helicobacter infection leads to a decrease in Shh expression in the stomach. Sonic Hedgehog (Shh) is highly expressed in the gastric corpus and its loss correlates with gastric atrophy. Therefore, we tested the hypothesis that proinfla...

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Main Authors: Waghray, Meghna, Zavros, Yana, Saqui-Salces, Milena, El-Zaatari, Mohamad, Alamelumangapuram, C. Bharath, Todisco, Andrea, Eaton, Kathryn A., Merchant, Juanita L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895809/
https://ncbi.nlm.nih.gov/pubmed/19883649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.10.043
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