Broad-Spectrum Matrix Metalloproteinase Inhibition Curbs Inflammation and Liver Injury but Aggravates Experimental Liver Fibrosis in Mice

BACKGROUND: Liver fibrosis is characterized by excessive synthesis of extracellular matrix proteins, which prevails over their enzymatic degradation, primarily by matrix metalloproteinases (MMPs). The effect of pharmacological MMP inhibition on fibrogenesis, however, is largely unexplored. Inflammat...

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Autores principales: de Meijer, Vincent E., Sverdlov, Deanna Y., Popov, Yury, Le, Hau D., Meisel, Jonathan A., Nosé, Vânia, Schuppan, Detlef, Puder, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892485/
https://ncbi.nlm.nih.gov/pubmed/20593020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011256
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