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Tissue Transglutaminase Does Not Affect Fibrotic Matrix Stability or Regression of Liver Fibrosis in Mice

BACKGROUND: The ubiquitous crosslinking enzyme tissue transglutaminase (TG2) has been implicated in irreversible collagen stabilization in liver fibrosis, although functional evidence is lacking. We studied the contribution of TG2 to hepatic fibrotic matrix stability, as well as liver fibrosis progr...

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Detalhes bibliográficos
Main Authors: Popov, Yury, Sverdlov, Deanna Y., Sharma, Anisha K., Bhaskar, K. Ramakrishnan, Li, Shaoyong, Freitag, Tobias L., Lee, James, Dieterich, Walburga, Melino, Gerry, Schuppan, Detlef
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374132/
https://ncbi.nlm.nih.gov/pubmed/21277850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.01.040
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