Broad-Spectrum Matrix Metalloproteinase Inhibition Curbs Inflammation and Liver Injury but Aggravates Experimental Liver Fibrosis in Mice

BACKGROUND: Liver fibrosis is characterized by excessive synthesis of extracellular matrix proteins, which prevails over their enzymatic degradation, primarily by matrix metalloproteinases (MMPs). The effect of pharmacological MMP inhibition on fibrogenesis, however, is largely unexplored. Inflammat...

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Detalhes bibliográficos
Main Authors: de Meijer, Vincent E., Sverdlov, Deanna Y., Popov, Yury, Le, Hau D., Meisel, Jonathan A., Nosé, Vânia, Schuppan, Detlef, Puder, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892485/
https://ncbi.nlm.nih.gov/pubmed/20593020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011256
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