Broad-Spectrum Matrix Metalloproteinase Inhibition Curbs Inflammation and Liver Injury but Aggravates Experimental Liver Fibrosis in Mice

BACKGROUND: Liver fibrosis is characterized by excessive synthesis of extracellular matrix proteins, which prevails over their enzymatic degradation, primarily by matrix metalloproteinases (MMPs). The effect of pharmacological MMP inhibition on fibrogenesis, however, is largely unexplored. Inflammat...

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Bibliografski detalji
Glavni autori: de Meijer, Vincent E., Sverdlov, Deanna Y., Popov, Yury, Le, Hau D., Meisel, Jonathan A., Nosé, Vânia, Schuppan, Detlef, Puder, Mark
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892485/
https://ncbi.nlm.nih.gov/pubmed/20593020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011256
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