ApoE mimetic peptide decreases Aβ production in vitro and in vivo

BACKGROUND: Apolipoprotein E (apoE) is postulated to affect brain Aβ levels through multiple mechanisms--by altering amyloid precursor protein (APP) processing, Aβ degradation, and Aβ clearance. We previously showed that an apoE-derived peptide containing a double repeat of the receptor-binding regi...

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Bibliographic Details
Main Authors: Minami, S Sakura, Cordova, Antoinette, Cirrito, John R, Tesoriero, Joseph A, Babus, Lenard W, Davis, Gary C, Dakshanamurthy, Sivanesan, Turner, R Scott, Pak, Daniel TS, Rebeck, G William, Paige, Mikell, Hoe, Hyang-Sook
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890633/
https://ncbi.nlm.nih.gov/pubmed/20406479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-16
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