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Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3xTg-AD mice

Fyn kinase phosphorylates tau and exacerbates Aβ-mediated synaptic dysfunction. However, Fyn also increases the non-pathological cleavage of amyloid precursor protein (APP), suggesting opposing roles for Fyn in the pathogenesis of Alzheimer’s disease (AD). To determine the effect of Fyn on both Aβ a...

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Detalhes bibliográficos
Main Authors: Minami, S. Sakura, Clifford, Thomas G., Hoe, Hyang-Sook, Matsuoka, Yasuji, Rebeck, G. William
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192904/
https://ncbi.nlm.nih.gov/pubmed/21741124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.05.014
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