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Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3xTg-AD mice
Fyn kinase phosphorylates tau and exacerbates Aβ-mediated synaptic dysfunction. However, Fyn also increases the non-pathological cleavage of amyloid precursor protein (APP), suggesting opposing roles for Fyn in the pathogenesis of Alzheimer’s disease (AD). To determine the effect of Fyn on both Aβ a...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3192904/ https://ncbi.nlm.nih.gov/pubmed/21741124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.05.014 |
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