Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis

Factor XII (FXII) and high molecular weight kininogen (HK) mutually block each other's binding to the urokinase plasminogen activator receptor (uPAR). We investigated if FXII stimulates cells by interacting with uPAR. FXII (3-62nM) with 0.05mM Zn(2+) induces extracellular signal-related kinase...

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書誌詳細
主要な著者: LaRusch, Gretchen A., Mahdi, Fakhri, Shariat-Madar, Zia, Adams, Gregory, Sitrin, Robert G., Zhang, Wan Ming, McCrae, Keith R., Schmaier, Alvin H.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2010
主題:
Vascular Biology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890145/
https://ncbi.nlm.nih.gov/pubmed/20228268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-236430
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