Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis

Factor XII (FXII) and high molecular weight kininogen (HK) mutually block each other's binding to the urokinase plasminogen activator receptor (uPAR). We investigated if FXII stimulates cells by interacting with uPAR. FXII (3-62nM) with 0.05mM Zn(2+) induces extracellular signal-related kinase...

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Autores principales: LaRusch, Gretchen A., Mahdi, Fakhri, Shariat-Madar, Zia, Adams, Gregory, Sitrin, Robert G., Zhang, Wan Ming, McCrae, Keith R., Schmaier, Alvin H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Vascular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890145/
https://ncbi.nlm.nih.gov/pubmed/20228268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-236430
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