Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis

Factor XII (FXII) and high molecular weight kininogen (HK) mutually block each other's binding to the urokinase plasminogen activator receptor (uPAR). We investigated if FXII stimulates cells by interacting with uPAR. FXII (3-62nM) with 0.05mM Zn(2+) induces extracellular signal-related kinase...

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Bibliographic Details
Main Authors: LaRusch, Gretchen A., Mahdi, Fakhri, Shariat-Madar, Zia, Adams, Gregory, Sitrin, Robert G., Zhang, Wan Ming, McCrae, Keith R., Schmaier, Alvin H.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2010
Subjects:
Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890145/
https://ncbi.nlm.nih.gov/pubmed/20228268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-236430
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