Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis

Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood vessel homeostasis. β-Galactosidase staining in PRCP(gt/gt) mice reveals expression in kidney and vasculature. Invas...

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Main Authors: Adams, Gregory N., LaRusch, Gretchen A., Stavrou, Evi, Zhou, Yihua, Nieman, Marvin T., Jacobs, Gretta H., Cui, Yingjie, Lu, Yuan, Jain, Mukesh K., Mahdi, Fakhri, Shariat-Madar, Zia, Okada, Yoshio, D'Alecy, Louis G., Schmaier, Alvin H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083303/
https://ncbi.nlm.nih.gov/pubmed/21297000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-318527
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