Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis

Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood vessel homeostasis. β-Galactosidase staining in PRCP(gt/gt) mice reveals expression in kidney and vasculature. Invas...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Adams, Gregory N., LaRusch, Gretchen A., Stavrou, Evi, Zhou, Yihua, Nieman, Marvin T., Jacobs, Gretta H., Cui, Yingjie, Lu, Yuan, Jain, Mukesh K., Mahdi, Fakhri, Shariat-Madar, Zia, Okada, Yoshio, D'Alecy, Louis G., Schmaier, Alvin H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2011
Témata:
Vascular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083303/
https://ncbi.nlm.nih.gov/pubmed/21297000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-318527
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky