Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis

Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood vessel homeostasis. β-Galactosidase staining in PRCP(gt/gt) mice reveals expression in kidney and vasculature. Invas...

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Detalhes bibliográficos
Main Authors: Adams, Gregory N., LaRusch, Gretchen A., Stavrou, Evi, Zhou, Yihua, Nieman, Marvin T., Jacobs, Gretta H., Cui, Yingjie, Lu, Yuan, Jain, Mukesh K., Mahdi, Fakhri, Shariat-Madar, Zia, Okada, Yoshio, D'Alecy, Louis G., Schmaier, Alvin H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083303/
https://ncbi.nlm.nih.gov/pubmed/21297000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-318527
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