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Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β(1)-integrin and VEGFR2
How single-chain urokinase (ScuPA) mediates angiogenesis is incompletely understood. ScuPA (≥4 nM) induces phosphorylated (p)ERK1/2 (MAPK44 and MAPK42) and pAkt (Ser(473)) in umbilical vein and dermal microvascular endothelial cells. Activation of pERK1/2 by ScuPA is blocked by PD-98059 or U-0126, a...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Physiological Society
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3742872/ https://ncbi.nlm.nih.gov/pubmed/23709605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00110.2013 |
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