Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β(1)-integrin and VEGFR2

How single-chain urokinase (ScuPA) mediates angiogenesis is incompletely understood. ScuPA (≥4 nM) induces phosphorylated (p)ERK1/2 (MAPK44 and MAPK42) and pAkt (Ser(473)) in umbilical vein and dermal microvascular endothelial cells. Activation of pERK1/2 by ScuPA is blocked by PD-98059 or U-0126, a...

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Bibliographische Detailangaben
Hauptverfasser: LaRusch, Gretchen A., Merkulova, Alona, Mahdi, Fakhri, Shariat-Madar, Zia, Sitrin, Robert G., Cines, Douglas B., Schmaier, Alvin H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2013
Schlagworte:
Vascular Biology and Microcirculation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742872/
https://ncbi.nlm.nih.gov/pubmed/23709605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00110.2013
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