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Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin

Bradykinin (BK) liberates nitric oxide, prostacyclin, and tissue plasminogen activator from endothelial cells. We hypothesized that BK B2 receptor knockout (KO) mice (BKB2R(-/-)) have increased thrombosis risk. Paradoxically, the BKB2R(-/-) mice have long bleeding times and delayed carotid artery th...

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Autori principali: Shariat-Madar, Zia, Mahdi, Fakhri, Warnock, Mark, Homeister, Jonathon W., Srikanth, Sujata, Krijanovski, Yelena, Murphey, Laine J., Jaffa, Ayad A., Schmaier, Alvin H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895832/
https://ncbi.nlm.nih.gov/pubmed/16514058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-0094
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