Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin

Bradykinin (BK) liberates nitric oxide, prostacyclin, and tissue plasminogen activator from endothelial cells. We hypothesized that BK B2 receptor knockout (KO) mice (BKB2R(-/-)) have increased thrombosis risk. Paradoxically, the BKB2R(-/-) mice have long bleeding times and delayed carotid artery th...

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Main Authors: Shariat-Madar, Zia, Mahdi, Fakhri, Warnock, Mark, Homeister, Jonathon W., Srikanth, Sujata, Krijanovski, Yelena, Murphey, Laine J., Jaffa, Ayad A., Schmaier, Alvin H.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Hematology 2006
Fag:
Hemostasis, Thrombosis, and Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895832/
https://ncbi.nlm.nih.gov/pubmed/16514058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-0094
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