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Oral Thrombostatin FM19 Inhibits Prostate Cancer

Thrombin stimulates proliferation, invasion and metastasis by cleaving PAR1 on a human prostate cancer cells. Current direct thrombin inhibitors pose risks for bleeding in the cancer patients. We have developed an oral reversible direct thrombin inhibitor called FM19. FM19 inhibits thrombin-induced...

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Detalhes bibliográficos
Main Authors: Nieman, Marvin T., LaRusch, Gretchen A., Fang, Chao, Zhou, Yihua, Schmaier, Alvin H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552554/
https://ncbi.nlm.nih.gov/pubmed/20886199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH09-08-0570
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