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Thrombostatin FM compounds: direct thrombin inhibitors – mechanism of action in vitro and in vivo

BACKGROUND: Novel pentapeptides called Thrombostatin FM compounds consisting mostly of D-isomers and unusual amino acids were prepared based upon the stable angiotensin converting enzyme breakdown product of bradykinin – RPPGF. METHODS AND RESULTS: These peptides are direct thrombin inhibitors prolo...

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Detalhes bibliográficos
Main Authors:	Nieman, M. T., Burke, F., Warnock, M., Zhou, Y., Sweigart, J., Chen, A., Ricketts, D., Lucchesi, B. R., Chen, Z., Di Cera, E., Hilfinger, J., Kim, J. S., Mosberg, H. I., Schmaier, A. H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	2008
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2652574/ https://ncbi.nlm.nih.gov/pubmed/18315550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2008.02937.x
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Thrombostatin FM compounds: direct thrombin inhibitors – mechanism of action in vitro and in vivo

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