Thrombostatin FM compounds: direct thrombin inhibitors – mechanism of action in vitro and in vivo

BACKGROUND: Novel pentapeptides called Thrombostatin FM compounds consisting mostly of D-isomers and unusual amino acids were prepared based upon the stable angiotensin converting enzyme breakdown product of bradykinin – RPPGF. METHODS AND RESULTS: These peptides are direct thrombin inhibitors prolo...

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Bibliografiske detaljer
Main Authors: Nieman, M. T., Burke, F., Warnock, M., Zhou, Y., Sweigart, J., Chen, A., Ricketts, D., Lucchesi, B. R., Chen, Z., Di Cera, E., Hilfinger, J., Kim, J. S., Mosberg, H. I., Schmaier, A. H.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652574/
https://ncbi.nlm.nih.gov/pubmed/18315550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2008.02937.x
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