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Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site
Investigations determined the critical amino acids for α-thrombin’s interaction with protease activated receptors 1 and 4 (PAR1 and PAR4) at the thrombin cleavage site. Recombinant PAR1-wild type (wt) exodomain was cleaved by α-thrombin with a K(m) of 28 μM, a k(cat) of 340 s(-1) and k(cat)/K(m) of...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2553362/ https://ncbi.nlm.nih.gov/pubmed/17595115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700597p |
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