Protease-activated Receptor 1 (PAR1) and PAR4 Heterodimers Are Required for PAR1-enhanced Cleavage of PAR4 by α-Thrombin

Thrombin is a potent platelet agonist that activates platelets and other cells of the cardiovascular system by cleaving its G-protein-coupled receptors, protease-activated receptor 1 (PAR1), PAR4, or both. We now show that cleaving PAR1 and PAR4 with α-thrombin induces heterodimer formation. PAR1-PA...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Arachiche, Amal, Mumaw, Michele M., de la Fuente, María, Nieman, Marvin T.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2013
נושאים:
Protein Structure and Folding
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820888/
https://ncbi.nlm.nih.gov/pubmed/24097976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.472373
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