uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells

Exosomes (Exos) have been reported to promote pre-metastatic niche formation, proliferation, angiogenesis and metastasis. We have investigated the role of uPAR in melanoma cell lines-derived Exos and their pro-angiogenic effects on human microvascular endothelial cells (HMVECs) and endothelial colon...

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Publicado en:Cell Mol Life Sci
Autores principales: Biagioni, Alessio, Laurenzana, Anna, Menicacci, Beatrice, Peppicelli, Silvia, Andreucci, Elena, Bianchini, Francesca, Guasti, Daniele, Paoli, Paolo, Serratì, Simona, Mocali, Alessandra, Calorini, Lido, Del Rosso, Mario, Fibbi, Gabriella, Chillà, Anastasia, Margheri, Francesca
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer International Publishing 2020
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8004497/
https://ncbi.nlm.nih.gov/pubmed/33237352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-020-03707-4
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