Dystrophin Isoform Induction In Vivo by Antisense-mediated Alternative Splicing

Antisense oligomer-induced manipulation of dystrophin pre-mRNA processing can remove exons carrying mutations, or exclude exons flanking frameshifting mutations, and restore dystrophin expression in dystrophinopathy models and in Duchenne muscular dystrophy (DMD) patients. Splice intervention can al...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Fletcher, Sue, Adams, Abbie M, Johnsen, Russell D, Greer, Kane, Moulton, Hong M, Wilton, Steve D
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2010
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889736/
https://ncbi.nlm.nih.gov/pubmed/20332768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.45
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