Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state

Mouse and rat embryonic stem cells can be sustained in defined medium by dual inhibition (2i) of the mitogen-activated protein kinase (Erk1/2) cascade and of glycogen synthase kinase 3. The inhibitors suppress differentiation and enable self-renewal of pluripotent cells that are ex vivo counterparts...

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Detaylı Bibliyografya
Asıl Yazarlar: Leitch, Harry G., Blair, Kate, Mansfield, William, Ayetey, Harold, Humphreys, Peter, Nichols, Jennifer, Surani, M. Azim, Smith, Austin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Company of Biologists 2010
Konular:
Development and Stem Cells
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889601/
https://ncbi.nlm.nih.gov/pubmed/20519324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.050427
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