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Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state
Mouse and rat embryonic stem cells can be sustained in defined medium by dual inhibition (2i) of the mitogen-activated protein kinase (Erk1/2) cascade and of glycogen synthase kinase 3. The inhibitors suppress differentiation and enable self-renewal of pluripotent cells that are ex vivo counterparts...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Company of Biologists
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889601/ https://ncbi.nlm.nih.gov/pubmed/20519324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.050427 |
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