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Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells

Inosine 5-monophosphate dehydrogenase II, a key enzyme in the de novo synthesis of purine nucleotides, is expressed in prostate tumors and prostate cancer cells. AVN944 is a new, specific, noncompetitive IMPDH inhibitor. In this study, we investigated the effects of IMPDH inhibitor AVN944 on LNCaP,...

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Detalhes bibliográficos
Main Authors: Floryk, Daniel, Thompson, Timothy C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887704/
https://ncbi.nlm.nih.gov/pubmed/18712736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23788
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