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Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice

Meiotic recombination is initiated by the programmed induction of DNA double-strand breaks (DSBs) catalyzed by the evolutionarily conserved Spo11 protein. Studies in yeast have shown that DSB formation requires several other proteins, the role and conservation of which remain unknown. Here we show t...

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Autors principals: Kumar, Rajeev, Bourbon, Henri-Marc, de Massy, Bernard
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885662/
https://ncbi.nlm.nih.gov/pubmed/20551173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.571710
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