Recognition and Processing of a New Repertoire of DNA Substrates by Human 3-Methyladenine DNA Glycosylase (AAG)

The human 3-methyladenine DNA glycosylase (AAG) recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine (Hx), and 1,N(6)-ethenoadenine (εA). The crystal structures of AAG bound to εA have provided insights i...

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Hauptverfasser: Lee, Chun-Yue I., Delaney, James C., Kartalou, Maria, Lingaraju, Gondichatnahalli M., Maor-Shoshani, Ayelet, Essigmann, John M., Samson, Leona D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883313/
https://ncbi.nlm.nih.gov/pubmed/19219989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8018898
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