Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD

BACKGROUND: Multidrug resistance-associated protein-1 (MRP1) protects against oxidative stress and toxic compounds generated by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease (COPD). We have previously shown that single nucleotide polymorphisms (SNPs) in M...

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Autori principali: Budulac, Simona E, Postma, Dirkje S, Hiemstra, Pieter S, Kunz, Lisette IZ, Siedlinski, Mateusz, Smit, Henriette A, Vonk, Judith M, Rutgers, Bea, Timens, Wim, Boezen, H Marike
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882908/
https://ncbi.nlm.nih.gov/pubmed/20487524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-11-60
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