Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD

BACKGROUND: Multidrug resistance-associated protein-1 (MRP1) protects against oxidative stress and toxic compounds generated by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease (COPD). We have previously shown that single nucleotide polymorphisms (SNPs) in M...

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Autors principals: Budulac, Simona E, Postma, Dirkje S, Hiemstra, Pieter S, Kunz, Lisette IZ, Siedlinski, Mateusz, Smit, Henriette A, Vonk, Judith M, Rutgers, Bea, Timens, Wim, Boezen, H Marike
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882908/
https://ncbi.nlm.nih.gov/pubmed/20487524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-11-60
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