Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins

VP35 is one of seven structural proteins encoded by the Ebola viral genome and mediates viral replication, nucleocapsid formation and host immune suppression. The C-terminal interferon inhibitory domain (IID) of VP35 is critical for dsRNA binding and interferon inhibition. The wild-type VP35 IID str...

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Autors principals: Leung, Daisy W., Borek, Dominika, Farahbakhsh, Mina, Ramanan, Parameshwaran, Nix, Jay C., Wang, Tianjiao, Prins, Kathleen C., Otwinowski, Zbyszek, Honzatko, Richard B., Helgeson, Luke A., Basler, Christopher F., Amarasinghe, Gaya K.
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2010
Matèries:
Crystallization Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882771/
https://ncbi.nlm.nih.gov/pubmed/20516601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110013266
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