Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain

Ebola VP35 is a multifunctional protein that is important for host immune suppression and pathogenesis. VP35 contains an N-terminal oligomerization domain and a C-terminal interferon inhibitory domain (IID). Mutations within the VP35 IID result in loss of host immune suppression. Here, efforts to cr...

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Main Authors: Leung, Daisy W., Ginder, Nathaniel D., Nix, Jay C., Basler, Christopher F., Honzatko, Richard B., Amarasinghe, Gaya K.
格式: Artigo
語言:Inglês
出版: International Union of Crystallography 2009
主題:
Crystallization Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635856/
https://ncbi.nlm.nih.gov/pubmed/19194011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309108044187
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