Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin

Sterol-regulatory element binding protein-1c (SREBP-1c) is a transcription factor that controls lipogenesis in the liver. Hepatic SREBP-1c is nutritionally regulated, and its sustained activation causes hepatic steatosis and insulin resistance. Although regulation of SREBP-1c is known to occur at th...

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Auteurs principaux: Yamamoto, Takashi, Watanabe, Kazuhisa, Inoue, Noriyuki, Nakagawa, Yoshimi, Ishigaki, Naomi, Matsuzaka, Takashi, Takeuchi, Yoshinori, Kobayashi, Kazuto, Yatoh, Shigeru, Takahashi, Akimitsu, Suzuki, Hiroaki, Yahagi, Naoya, Gotoda, Takanari, Yamada, Nobuhiro, Shimano, Hitoshi
Format: Artigo
Langue:Inglês
Publié: The American Society for Biochemistry and Molecular Biology 2010
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882723/
https://ncbi.nlm.nih.gov/pubmed/20179320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M004234
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