Polyunsaturated Fatty Acids Selectively Suppress Sterol Regulatory Element-binding Protein-1 through Proteolytic Processing and Autoloop Regulatory Circuit

Sterol regulatory element-binding protein (SREBP)-1 is a key transcription factor for the regulation of lipogenic enzyme genes in the liver. Polyunsaturated fatty acids (PUFA) selectively suppress hepatic SREBP-1, but molecular mechanisms remain largely unknown. To gain insight into this regulation,...

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Main Authors: Takeuchi, Yoshinori, Yahagi, Naoya, Izumida, Yoshihiko, Nishi, Makiko, Kubota, Midori, Teraoka, Yuji, Yamamoto, Takashi, Matsuzaka, Takashi, Nakagawa, Yoshimi, Sekiya, Motohiro, Iizuka, Yoko, Ohashi, Ken, Osuga, Jun-ichi, Gotoda, Takanari, Ishibashi, Shun, Itaka, Keiji, Kataoka, Kazunori, Nagai, Ryozo, Yamada, Nobuhiro, Kadowaki, Takashi, Shimano, Hitoshi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857043/
https://ncbi.nlm.nih.gov/pubmed/20145241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.096107
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