Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice

F-box and WD repeat domain-containing 7α (Fbw7α) is the substrate recognition component of a ubiquitin ligase that controls the degradation of factors involved in cellular growth, including c-Myc, cyclin E, and c-Jun. In addition, Fbw7α degrades the nuclear form of sterol regulatory element-binding...

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Detalhes bibliográficos
Main Authors: Kumadaki, Shin, Karasawa, Tadayoshi, Matsuzaka, Takashi, Ema, Masatsugu, Nakagawa, Yoshimi, Nakakuki, Masanori, Saito, Ryo, Yahagi, Naoya, Iwasaki, Hitoshi, Sone, Hirohito, Takekoshi, Kazuhiro, Yatoh, Shigeru, Kobayashi, Kazuto, Takahashi, Akimitsu, Suzuki, Hiroaki, Takahashi, Satoru, Yamada, Nobuhiro, Shimano, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220464/
https://ncbi.nlm.nih.gov/pubmed/21911492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.235283
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