Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets

OBJECTIVE—Chronic exposure to fatty acids causes β-cell failure, often referred to as lipotoxicity. We investigated its mechanisms, focusing on contribution of SREBP-1c, a key transcription factor for lipogenesis. RESEARCH DESIGN AND METHODS—We studied in vitro and in vivo effects of saturated and p...

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Autors principals: Kato, Toyonori, Shimano, Hitoshi, Yamamoto, Takashi, Ishikawa, Mayumi, Kumadaki, Shin, Matsuzaka, Takashi, Nakagawa, Yoshimi, Yahagi, Naoya, Nakakuki, Masanori, Hasty, Alyssa H., Takeuchi, Yoshinori, Kobayashi, Kazuto, Takahashi, Akimitsu, Yatoh, Shigeru, Suzuki, Hiroaki, Sone, Hirohito, Yamada, Nobuhiro
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2008
Matèries:
Islet Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518489/
https://ncbi.nlm.nih.gov/pubmed/18458149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db06-1806
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