Cyclin-dependent Kinase Inhibitor, p21(WAF1/CIP1), Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to Obesity, and Insulin Resistance

Both adipocyte hyperplasia and hypertrophy are determinant factors for adipocyte differentiation during the development of obesity. p21(WAF1/CIP1), a cyclin-dependent kinase inhibitor, is induced during adipocyte differentiation; however, its precise contribution to this process is unknown. Using bo...

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Main Authors: Inoue, Noriyuki, Yahagi, Naoya, Yamamoto, Takashi, Ishikawa, Mayumi, Watanabe, Kazuhisa, Matsuzaka, Takashi, Nakagawa, Yoshimi, Takeuchi, Yoshinori, Kobayashi, Kazuto, Takahashi, Akimitsu, Suzuki, Hiroaki, Hasty, Alyssa H., Toyoshima, Hideo, Yamada, Nobuhiro, Shimano, Hitoshi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258954/
https://ncbi.nlm.nih.gov/pubmed/18445590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801824200
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