Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies

Monosomy 7 and del(7q) are associated with adverse features in myeloid malignancies. A 2.5-Mb commonly deleted segment (CDS) of chromosome band 7q22 is implicated as harboring a myeloid tumor suppressor gene (TSG); however, molecular analysis of candidate TSGs has not uncovered loss of function. To...

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Detalhes bibliográficos
Main Authors: Wong, Jasmine C. Y., Zhang, Yan, Lieuw, Kenneth H., Tran, Mary T., Forgo, Erna, Weinfurtner, Kelley, Alzamora, Pilar, Kogan, Scott C., Akagi, Keiko, Wolff, Linda, Le Beau, Michelle M., Killeen, Nigel, Shannon, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881500/
https://ncbi.nlm.nih.gov/pubmed/20233966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-232504
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