Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies

Monosomy 7 and del(7q) are associated with adverse features in myeloid malignancies. A 2.5-Mb commonly deleted segment (CDS) of chromosome band 7q22 is implicated as harboring a myeloid tumor suppressor gene (TSG); however, molecular analysis of candidate TSGs has not uncovered loss of function. To...

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Autors principals: Wong, Jasmine C. Y., Zhang, Yan, Lieuw, Kenneth H., Tran, Mary T., Forgo, Erna, Weinfurtner, Kelley, Alzamora, Pilar, Kogan, Scott C., Akagi, Keiko, Wolff, Linda, Le Beau, Michelle M., Killeen, Nigel, Shannon, Kevin
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881500/
https://ncbi.nlm.nih.gov/pubmed/20233966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-232504
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