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Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic components including damaged organelles and proteins. In both genetic and dietary models of obesity, we observed a severe downregulation of autophagy, particularly in Atg7 expression levels in liver. Suppression of At...

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Detalhes bibliográficos
Main Authors: Yang, Ling, Li, Ping, Fu, Suneng, Calay, Ediz S., Hotamisligil, Gökhan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881480/
https://ncbi.nlm.nih.gov/pubmed/20519119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.04.005
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