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Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic components including damaged organelles and proteins. In both genetic and dietary models of obesity, we observed a severe downregulation of autophagy, particularly in Atg7 expression levels in liver. Suppression of At...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2881480/ https://ncbi.nlm.nih.gov/pubmed/20519119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.04.005 |
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