Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

We report that rapamycin, an allosteric inhibitor of certain but not all actions of the key cellular kinase mammalian target of rapamycin (mTOR), protects neurons from death in both cellular and animal toxin models of Parkinson's disease (PD). This protective action appears to be attributable t...

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Hauptverfasser: Malagelada, Cristina, Jin, Zong Hao, Jackson-Lewis, Vernice, Przedborski, Serge, Greene, Lloyd A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880868/
https://ncbi.nlm.nih.gov/pubmed/20089925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3944-09.2010
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