Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease

Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease, can be recapitulated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice. Herein, we demonstrate that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T...

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Autors principals: Benner, Eric J., Mosley, R. Lee, Destache, Chris J., Lewis, Travis B., Jackson-Lewis, Vernice, Gorantla, Santhi, Nemachek, Craig, Green, Steven R., Przedborski, Serge, Gendelman, Howard E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC438994/
https://ncbi.nlm.nih.gov/pubmed/15197276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400569101
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