Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

Recent evidence indicates that cyclin-dependent kinases (CDKs, cdks) may be inappropriately activated in several neurodegenerative conditions. Here, we report that cdk5 expression and activity are elevated after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a toxin that dama...

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Detalhes bibliográficos
Main Authors: Smith, Patrice D., Crocker, Stephen J., Jackson-Lewis, Vernice, Jordan-Sciutto, Kelly L., Hayley, Shawn, Mount, Matthew P., O'Hare, Michael J., Callaghan, Steven, Slack, Ruth S., Przedborski, Serge, Anisman, Hymie, Park, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC263868/
https://ncbi.nlm.nih.gov/pubmed/14595022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2232515100
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