Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease

The molecular mechanisms mediating degeneration of midbrain dopamine neurons in Parkinson's disease (PD) are poorly understood. Here, we provide evidence to support a role for the involvement of the calcium-dependent proteases, calpains, in the loss of dopamine neurons in a mouse model of PD. W...

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Detaylı Bibliyografya
Yayımlandı:J Neurosci
Asıl Yazarlar: Crocker, Stephen J., Smith, Patrice D., Jackson-Lewis, Vernice, Lamba, Wiplore R., Hayley, Shawn P., Grimm, Erich, Callaghan, Steve M., Slack, Ruth S., Melloni, Edon, Przedborski, Serge, Robertson, George S., Anisman, Hymie, Merali, Zul, Park, David S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2003
Konular:
Cellular/Molecular
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741113/
https://ncbi.nlm.nih.gov/pubmed/12764095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-10-04081.2003
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