Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease

The molecular mechanisms mediating degeneration of midbrain dopamine neurons in Parkinson's disease (PD) are poorly understood. Here, we provide evidence to support a role for the involvement of the calcium-dependent proteases, calpains, in the loss of dopamine neurons in a mouse model of PD. W...

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Vydáno v:J Neurosci
Hlavní autoři: Crocker, Stephen J., Smith, Patrice D., Jackson-Lewis, Vernice, Lamba, Wiplore R., Hayley, Shawn P., Grimm, Erich, Callaghan, Steve M., Slack, Ruth S., Melloni, Edon, Przedborski, Serge, Robertson, George S., Anisman, Hymie, Merali, Zul, Park, David S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2003
Témata:
Cellular/Molecular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741113/
https://ncbi.nlm.nih.gov/pubmed/12764095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-10-04081.2003
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