Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease

The molecular mechanisms mediating degeneration of midbrain dopamine neurons in Parkinson's disease (PD) are poorly understood. Here, we provide evidence to support a role for the involvement of the calcium-dependent proteases, calpains, in the loss of dopamine neurons in a mouse model of PD. W...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Crocker, Stephen J., Smith, Patrice D., Jackson-Lewis, Vernice, Lamba, Wiplore R., Hayley, Shawn P., Grimm, Erich, Callaghan, Steve M., Slack, Ruth S., Melloni, Edon, Przedborski, Serge, Robertson, George S., Anisman, Hymie, Merali, Zul, Park, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741113/
https://ncbi.nlm.nih.gov/pubmed/12764095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-10-04081.2003
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