Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease

In Parkinson's disease (PD), there is a progressive loss of neuromelanin (NM)-containing dopamine (DA) neurons in substantia nigra (SN) which is associated with microgliosis and presence of extracellular NM. Herein, we have investigated the interplay between microglia and human NM on the degene...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhang, Wei, Phillips, Kester, Wielgus, Albert R., Liu, Jie, Albertini, Alberto, Zucca, Fabio A., Faust, Rudolph, Qian, Steven Y., Miller, David S., Chignell, Colin F., Wilson, Belinda, Jackson-Lewis, Vernice, Przedborski, Serge, Joset, Danielle, Loike, John, Hong, Jau-Shyong, Sulzer, David, Zecca, Luigi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603276/
https://ncbi.nlm.nih.gov/pubmed/19957214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-009-9140-z
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