Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease

In Parkinson's disease (PD), there is a progressive loss of neuromelanin (NM)-containing dopamine (DA) neurons in substantia nigra (SN) which is associated with microgliosis and presence of extracellular NM. Herein, we have investigated the interplay between microglia and human NM on the degene...

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Detalhes bibliográficos
Main Authors: Zhang, Wei, Phillips, Kester, Wielgus, Albert R., Liu, Jie, Albertini, Alberto, Zucca, Fabio A., Faust, Rudolph, Qian, Steven Y., Miller, David S., Chignell, Colin F., Wilson, Belinda, Jackson-Lewis, Vernice, Przedborski, Serge, Joset, Danielle, Loike, John, Hong, Jau-Shyong, Sulzer, David, Zecca, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603276/
https://ncbi.nlm.nih.gov/pubmed/19957214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-009-9140-z
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